PDE8B antibody (AA 296-324)

Catalog No. ABIN5538156

Product Details anti-PDE8B Antibody

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Binding Specificity: AA 296-324

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDE8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the Central region of human PDE8B.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B (PDE8B Products)

Synonyms: PDE8B antibody, ADSD antibody, PPNAD3 antibody, B230331L10Rik antibody, C030047E14Rik antibody, RNPDE8B antibody, phosphodiesterase 8B antibody, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B antibody, PDE8B antibody, LOC100468338 antibody, pde8b antibody, Pde8b antibody

Background: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 99 kDa

Gene ID: 8622

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process