PDE8B Products
(phosphodiesterase 8B (PDE8B))
Categories
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010].
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Featured PDE8B Categories
PDE8B Antibodies
High quality antibodies with extensive validation data.
Recommended PDE8B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB
Validations
- (3)
- (1)
Cat. No.
ABIN1881646
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Bat, Horse, Human, Monkey
Application
IHC (p), IHC
Validations
- (2)
Cat. No.
ABIN213535
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF
Validations
- (1)
Cat. No.
ABIN7155168
Quantity
100 μL
Datasheet
Datasheet
Recommended PDE8B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3094523
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3131150
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PDE8B products
: "Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels." in: Thyroid : official journal of the American Thyroid Association, Vol. 20, Issue 4, pp. 363-7, (2010) (PubMed).: "Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy." in: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 11, pp. 4608-12, (2009) (PubMed).
: "Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 1, pp. 153-61, (2009) (PubMed).
: "A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex." in: European journal of human genetics : EJHG, Vol. 16, Issue 10, pp. 1245-53, (2008) (PubMed).
Synonyms and alternative names related to PDE8B
phosphodiesterase 8B (PDE8B), high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (LOC100468338), phosphodiesterase 8B (pde8b), phosphodiesterase 8B (Pde8b), ADSD, B230331L10Rik, C030047E14Rik, PDE8B, PPNAD3, RNPDE8BProtein level used designations for PDE8B
- phosphodiesterase 8B
- high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
- high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B-like
- 3',5' cyclic nucleotide phosphodiesterase 8B
- cell proliferation-inducing gene 22 protein
- high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
- hsPDE8B
- cAMP-specific cyclic nucleotide phosphodiesterase PDE8
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