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CRYAA antibody

CRYAA Reactivity: Human, Rat, Mouse, Cow WB, EIA Host: Mouse Monoclonal 1H3-B8 unconjugated
Catalog No. ABIN453938
  • Target See all CRYAA Antibodies
    CRYAA (Crystallin, alpha A (CRYAA))
    Reactivity
    • 45
    • 17
    • 16
    • 3
    • 1
    Human, Rat, Mouse, Cow
    Host
    • 28
    • 17
    • 1
    Mouse
    Clonality
    • 28
    • 18
    Monoclonal
    Conjugate
    • 20
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CRYAA antibody is un-conjugated
    Application
    • 34
    • 26
    • 17
    • 11
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody recognizes Alpha A Crystallin at ~20 kDa. Detects alpha Crystallin complex (containing Alpha A and Alpha B subunits). Does not cross react with Alpha B Crystallin, Beta-L Crystallin, Beta-H Crystallin, Gamma Crystallin, Hsp25, Hsp27 or Hsp47 proteins.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Cow, Rat.
    Characteristics
    Synonyms: CRYAA, CRYA1, HSPB4, Heat shock protein beta-4
    Purification
    Protein G affinity chroamtography
    Immunogen
    Native alpha crystallin
    Clone
    1H3-B8
    Isotype
    IgG1
    Top Product
    Discover our top product CRYAA Primary Antibody
  • Application Notes
    Western blot: 1/2000. ELISA.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS pH 7.2, 0.09 % Sodium Azide, 50 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    CRYAA (Crystallin, alpha A (CRYAA))
    Alternative Name
    alpha-Crystallin A Chain (CRYAA Products)
    Synonyms
    CRYA1 antibody, CTRCT9 antibody, HSPB4 antibody, AI323437 antibody, Acry-1 antibody, Crya-1 antibody, Crya1 antibody, DAcry-1 antibody, lop18 antibody, alpha-a-crystallin antibody, cryaa-A antibody, CRYAA antibody, wu:fc06h04 antibody, zgc:92036 antibody, HspB4 antibody, crystallin alpha A antibody, crystallin, alpha A antibody, alphaA-crystallin antibody, alpha-crystallin A chain-like antibody, crystallin alpha A S homeolog antibody, alpha-crystallin A chain antibody, CRYAA antibody, Cryaa antibody, CpipJ_CPIJ005646 antibody, cryaa antibody, LOC100384978 antibody, cryaa.S antibody, LOC458589 antibody, LOC102724652 antibody
    Background
    The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alphacrystallins possess structural and functional similarities with Hsp25 and Hsp27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8).Synonyms: CRYA1, CRYAA, HSPB4, Heat shock protein beta-4
    Gene ID
    1409
    UniProt
    P02489
    Pathways
    M Phase
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