TICAM2 antibody (C-Term)

Catalog No. ABIN500931

Product Details anti-TICAM2 Antibody

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TICAM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects TICAM2 / TRAM.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Ion exchange chromatography

Immunogen: TIRP antibody was raised against a peptide corresponding to amino acids near the C- terminus of human TIRP.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 to 2 μg/mL. Immunohistochemistry on parffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

References for anti-TICAM2 antibody (ABIN500931)

Ye, Yang, Chen, Li, Jia, Su, Wang, He: "Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway." in: Stem cells international, Vol. 2017, pp. 5841814, (2017) (PubMed).

Landais, Pelton, Streblow, DeFilippis, McWeeney, Nelson: "Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway." in: PLoS pathogens, Vol. 11, Issue 5, pp. e1004881, (2016) (PubMed).

Target Details for TICAM2

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Alternative Name: TICAM2 / TRAM (TICAM2 Products)

Synonyms: MyD88-4 antibody, TICAM-2 antibody, TIRAP3 antibody, TIRP antibody, TRAM antibody, B430113A10 antibody, Tirp antibody, Trif antibody, toll like receptor adaptor molecule 2 antibody, toll-like receptor adaptor molecule 2 antibody, TICAM2 antibody, Ticam2 antibody

Background: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).Synonyms: Putative NF-kappa-B-activating protein 502, TICAM-2, TIR domain-containing adapter molecule 2, TIRAP3, TIRP, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein

Gene ID: 353376

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades