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RNF216 antibody (N-Term)

RNF216 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN501040
  • Target See all RNF216 Antibodies
    RNF216 (Ring Finger Protein 216 (RNF216))
    Binding Specificity
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 37
    • 30
    • 19
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 38
    Rabbit
    Clonality
    • 38
    Polyclonal
    Conjugate
    • 19
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNF216 antibody is un-conjugated
    Application
    • 16
    • 13
    • 9
    • 9
    • 7
    • 7
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects RNF216 / TRIAD3.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Ion exchange chromatography
    Immunogen
    TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.
    Isotype
    IgG
    Top Product
    Discover our top product RNF216 Primary Antibody
  • Application Notes
    ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    RNF216 (Ring Finger Protein 216 (RNF216))
    Alternative Name
    RNF216 (RNF216 Products)
    Synonyms
    RGD1565135 antibody, TRIAD3 antibody, RNF216 antibody, zin antibody, u7i1 antibody, triad3 antibody, ubce7ip1 antibody, MGC147026 antibody, 2810055g22rik antibody, 2810055G22Rik antibody, AI647468 antibody, AU019462 antibody, C86502 antibody, F830018F18Rik antibody, UIP83 antibody, Ubce7ip1 antibody, CAHH antibody, U7I1 antibody, UBCE7IP1 antibody, ZIN antibody, ring finger protein 216 antibody, Rnf216 antibody, RNF216 antibody, rnf216 antibody
    Background
    Activation of NF-kappaB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2). Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR (3,4). Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase (5). TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9, this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation (5).Synonyms: E3 ubiquitin-protein ligase RNF216, RING finger protein 216, TRIAD3, Triad domain-containing protein 3, UBCE7IP1, Ubiquitin-conjugating enzyme 7-interacting protein 1, ZIN, Zinc finger protein inhibiting NF-kappa-B
    Gene ID
    54476
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