NOX1 antibody (Internal Region)

Catalog No. ABIN784273

Product Details anti-NOX1 Antibody

Target: NOX1 (NADPH Oxidase 1 (NOX1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This NOX1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-DKATDIVTGL KQK

Specificity: This antibody is expected to recognize both reported isoforms (NP_008983.2, NP_39249.1).

Cross-Reactivity (Details): Species reactivity (expected):Canine (Dog), Bovine.
Species reactivity (tested):Human, Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_008983.2, NP_39249.1. Genename: NOX1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NOX1

Target: NOX1 (NADPH Oxidase 1 (NOX1))

Alternative Name: NOX-1 (NOX1 Products)

Synonyms: GP91-2 antibody, MOX1 antibody, NOH-1 antibody, NOH1 antibody, NOX1a antibody, NOX1alpha antibody, Nox-1 antibody, Nox1 antibody, NADPH oxidase 1 antibody, NOX1 antibody, Nox1 antibody, nox1 antibody

Background: The NOX family NADPH protein oxidases are involved in transfer of electrons accross membranes to generate reactive oxygen species. There are 7 family members - NOX1-5, DUOX1 and DUOX2. Expression of NOX1 is highest in colon tissue, it is also found in vascular tissue and can also been induced by a variety of factors including PDGF. It requires interaction with NOXO1 and NOXA1 for superoxide generation.Synonyms: Mitogenic oxidase 1, NADH/NADPH mitogenic oxidase subunit P65-MOX, NADPH oxidase 1, NOH1

Gene ID: 27035

NCBI Accession: NP_008983

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Proton Transport