TLR7 antibody (AA 500-900) (FITC)

Catalog No. ABIN5564263

Product Details anti-TLR7 Antibody (FITC)

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Binding Specificity: AA 500-900

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR7 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: Recognizes human TLR7.

Cross-Reactivity: Human

Purification: Protein G purified.

Immunogen: Recombinant human TLR7 protein (aa 500-900).

Clone: ABM2C27

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In 10 mM TRIS containing 150 mM NaCl and 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 6 months after receipt when stored at +4°C.

Expiry Date: 6 months

Target Details for TLR7

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Alternative Name: TLR7 (TLR7 Products)

Synonyms: TLR7-like antibody, RGD1563357 antibody, toll like receptor 7 antibody, toll-like receptor 7 antibody, TLR7 antibody, Tlr7 antibody

Background: TLR7 (Toll-like Receptor 7) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is a nucleotide-sensing TLR. TLR7 and TLR8 recognize single-stranded RNA (ssRNA) sequences containing GU-rich or poly-U sequences as their natural ligands, and they are also activated by synthetic small-molecular-weight compounds of the imidazoquinoline family. Both TLR7 and TLR8 signal via MYD88 and TRAF6, leading to NF-kappaB and antiviral factor, such as IRF family activation, cytokine secretion and the inflammatory response. They are localized intracellularly to endosomal membranes and act as potent activators of innate immune responses upon viral infection. The TLR7 gene is predominantly expressed in lung, placenta and spleen, and lies in close proximity to TLR8 on chromosome X. TLR7 has been shown to play a significant role in the pathogenesis of autoimmune disorders such as Systemic Lupus Erythematosus (SLE) as well as in the regulation of antiviral immunity. Recently, small molecule TLR7/8 agonists have demonstrated potential as vaccine adjuvants, since they directly activate APCs and can enhance both humoral and cellular immune responses, especially Th1 responses. This makes the TLR7/8 signaling pathways interesting therapeutic targets.

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades