Amyloid Oligomers antibody

Catalog No. ABIN950404

Product Details

Target: Amyloid Oligomers

Reactivity: Human, Mouse, Rat, Eukaryotes

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Dot Blot (DB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Recognizes all types of Amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to Amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Cross-Reactivity (Details): Species reactivity (tested):Human, Eukaryotes, Rat and Mouse.

Purification: Protein A Chromatography

Immunogen: Synthetic molecular mimic of soluble oligomers.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS, 0.09 % Sodium Azide, 50 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details

Target: Amyloid Oligomers

Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).Synonyms: A11, Amyloid Oligomer AlphaBeta, amyloid, oligomers

Gene ID: 351