MXD1 antibody

Catalog No. ABIN5647191

Product Details anti-MXD1 Antibody

Target: MXD1 (MAX Dimerization Protein 1 (MXD1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MXD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Expected species reactivity: Human

Purification: Antigen affinity purified

Immunogen: A recombinant human protein corresponding to amino acids M1-L221 was used as the immunogen for the MAD antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MAD antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the MAD antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for MXD1

Target: MXD1 (MAX Dimerization Protein 1 (MXD1))

Alternative Name: MAD / MXD1 / Max dimerization protein 1 (MXD1 Products)

Synonyms: MXD1 antibody, si:dkey-202n14.4 antibody, xmad1 antibody, BHLHC58 antibody, MAD antibody, MAD1 antibody, AW122478 antibody, Mad antibody, Mad1 antibody, Mad-1 antibody, MAX dimerization protein 1 antibody, MAX dimerization protein 1 L homeolog antibody, max dimerization protein 1 antibody, MXD1 antibody, mxd1 antibody, mxd1.L antibody, Mxd1 antibody

Background: MAD protein is a protein that in humans is encoded by the MXD1 gene. This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniProt: Q05195