NMNAT1 antibody (AA 171-201)

Catalog No. ABIN5647421

Product Details anti-NMNAT1 Antibody

Target: NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1))

Binding Specificity: AA 171-201

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMNAT1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity (Details): Expected species reactivity: Bovine

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 171-201 from the human protein was used as the immunogen for the NMNAT1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Western blot: 1:1000-2000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the NMNAT1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for NMNAT1

Target: NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1))

Alternative Name: NMNAT1 / Nicotinamide-nucleotide adenylyltransferase 1 (NMNAT1 Products)

Synonyms: id:ibd5068 antibody, im:7144541 antibody, zgc:110243 antibody, LCA9 antibody, NMNAT antibody, PNAT1 antibody, 2610529L11Rik antibody, 5730441G13Rik antibody, D4Cole1e antibody, nmnat antibody, nicotinamide mononucleotide adenylyltransferase 1 antibody, nicotinamide nucleotide adenylyltransferase 1 antibody, CpipJ_CPIJ015320 antibody, PTRG_06486 antibody, nmnat1 antibody, NMNAT1 antibody, Nmnat1 antibody

Background: Nicotinamide mononucleotide adenylyltransferase 1 catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form, nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.

Gene ID: 64802

UniProt: Q9HAN9