R-Spondin 3 antibody (AA 214-248)

Catalog No. ABIN5647910

Product Details anti-R-Spondin 3 Antibody

Target: R-Spondin 3 (RSPO3)

Binding Specificity: AA 214-248

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This R-Spondin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 214-248 from the human protein was used as the immunogen for the RSPO3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Western blot: 1:1000-2000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the RSPO3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for R-Spondin 3

Target: R-Spondin 3 (RSPO3)

Alternative Name: RSPO3 / R-spondin 3 (RSPO3 Products)

Synonyms: pwtsr antibody, thsd2 antibody, cristin1 antibody, CRISTIN1 antibody, PWTSR antibody, THSD2 antibody, RGD1563246 antibody, 2810459H04Rik antibody, AW742308 antibody, Cristin1 antibody, Thsd2 antibody, R-spondin 3 antibody, rspo3 antibody, RSPO3 antibody, Rspo3 antibody

Background: R-spondin-3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Gene ID: 84870

UniProt: Q9BXY4