MAPKBP1 antibody (AA 1-100)

Catalog No. ABIN5664104

The Rabbit Polyclonal anti-MAPKBP1 antibody has been validated for WB. It is suitable to detect MAPKBP1 in samples from Human.

Quick Overview for MAPKBP1 antibody (AA 1-100) (ABIN5664104)

Target: MAPKBP1 (Mitogen-Activated Protein Kinase Binding Protein 1 (MAPKBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAPKBP1 Antibody

Binding Specificity: AA 1-100

Sequence: MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MAPKBP1

Target: MAPKBP1 (Mitogen-Activated Protein Kinase Binding Protein 1 (MAPKBP1))

Alternative Name: MAPKBP1

Background: This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.,MAPKBP1,JNKBP-1,JNKBP1,NPHP20,Signal Transduction,Kinase,MAPKBP1

Molecular Weight: 23 kDa/109 kDa/134 kDa/149 kDa/163 kDa

Gene ID: 23005

UniProt: O60336