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Recombinant IL-6R (Tocilizumab Biosimilar) antibody

Reactivity: Human ELISA, InhA Host: Human Monoclonal RhPM-1 unconjugated Recombinant Antibody
Catalog No. ABIN5668253
  • Target See all IL-6R (Tocilizumab Biosimilar) products
    IL-6R (Tocilizumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    Human
    Clonality
    • 3
    Monoclonal
    Conjugate
    • 3
    This IL-6R (Tocilizumab Biosimilar) antibody is un-conjugated
    Application
    • 3
    • 1
    • 1
    ELISA, Inhibition Assay (InhA)
    Specificity
    Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
    Clone
    RhPM-1
    Isotype
    IgG1 kappa
  • Application Notes
    Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
    Comment

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Hsieh, Hsu, Chang, Lai: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).

  • Target
    IL-6R (Tocilizumab Biosimilar)
    Abstract
    IL-6R (Tocilizumab Biosimilar) Products
    Synonyms
    CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, interleukin 6 receptor antibody, IL6R antibody
    Target Type
    Biosimilar
    Background
    IL6R, MRA, atlizumab
    UniProt
    A0N0L5
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