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Recombinant IL-6R (Tocilizumab Biosimilar) antibody

Reactivity: Human ELISA, InhA Host: Rabbit Monoclonal RhPM-1 unconjugated Recombinant Antibody
Catalog No. ABIN5668254
  • Target See all IL-6R (Tocilizumab Biosimilar) products
    IL-6R (Tocilizumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 3
    Monoclonal
    Conjugate
    • 3
    This IL-6R (Tocilizumab Biosimilar) antibody is un-conjugated
    Application
    • 3
    • 1
    • 1
    ELISA, Inhibition Assay (InhA)
    Specificity
    Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
    Clone
    RhPM-1
    Isotype
    IgG kappa
  • Application Notes
    Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
    Comment

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    IL-6R (Tocilizumab Biosimilar)
    Abstract
    IL-6R (Tocilizumab Biosimilar) Products
    Synonyms
    CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, interleukin 6 receptor antibody, IL6R antibody
    Target Type
    Biosimilar
    Background
    IL6R, MRA, atlizumab
    UniProt
    A0N0L5
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