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Vinculin antibody (AA 50-100)
VCL
Reactivity: Human, Mouse, Rat, Rabbit, Chicken
WB, ELISA
Host: Mouse
Monoclonal
7E10
unconjugated
Product Details anti-Vinculin Antibody
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Target
See all Vinculin (VCL) Antibodies
Vinculin (VCL)
Binding Specificity
All epitopes for Vinculin antibodies
AA 50-100
Reactivity
All reactivities for Vinculin antibodies
Human, Mouse, Rat, Rabbit, Chicken
Host
All hosts for Vinculin antibodies
Mouse
Clonality
All clonalities for Vinculin antibodies
Monoclonal
Conjugate
All conjugates for Vinculin antibodies
This Vinculin antibody is un-conjugated
Application
All applications for Vinculin antibodies
Western Blotting (WB), ELISA
Specificity
Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.
Purification
Vinculin antibody is purified via Protein A prification.
Immunogen
Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin. The immunogen is located within amino acids 50 - 100 of Vinculin.
Clone
7E10
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Vinculin antibody can be used for detection of Vinculin by Western blot at 0.5 - 1 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Vinculin Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Vinculin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for Vinculin
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Target
Vinculin (VCL)
Alternative Name
Vinculin (VCL Products )
Synonyms
CMD1W antibody, CMH15 antibody, MV antibody, MVCL antibody, VCL antibody, im:6902790 antibody, hm:zehn2160 antibody, DDBDRAFT_0186762 antibody, DDBDRAFT_0232320 antibody, DDB_0186762 antibody, DDB_0232320 antibody, 9430097D22 antibody, AA571387 antibody, AI462105 antibody, AW545629 antibody, CG3299 antibody, CT11081 antibody, Dmel\\CG3299 antibody, Dmvincp antibody, EG:103B4.1 antibody, Vin antibody, Vin2EF antibody, vinc antibody, LOC100228062 antibody, vcl-A antibody, vinculin antibody, vinculin a antibody, vinculin A antibody, Vinculin antibody, vinculin S homeolog antibody, VCL antibody, vcla antibody, vinA antibody, Vcl antibody, Vinc antibody, CpipJ_CPIJ013873 antibody, Bm1_37935 antibody, vcl antibody, vcl.S antibody
Background
Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).
Molecular Weight
Predicted: 117 kDa Observed: 120 kDa
Gene ID
7414
NCBI Accession
NP_003364
Pathways
Cell-Cell Junction Organization , Maintenance of Protein Location , Signaling Events mediated by VEGFR1 and VEGFR2
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