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SYK antibody (AA 321-325)
SYK
Reactivity: Human
WB, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SYK Antibody
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Target
See all SYK Antibodies
SYK
(Spleen tyrosine Kinase (SYK))
Binding Specificity
All epitopes for SYK antibodies
AA 321-325
Reactivity
All reactivities for SYK antibodies
Human
Host
All hosts for SYK antibodies
Rabbit
Clonality
All clonalities for SYK antibodies
Polyclonal
Conjugate
All conjugates for SYK antibodies
This SYK antibody is un-conjugated
Application
All applications for SYK antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Specificity
This antibody detects endogenous level of total syk protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
syk (Ab-323) antibody was raised against a peptide sequence around aa. 321~325 (N-P-Y-E-P) derived from Human syk.
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Alternatives
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Application Details
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Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for SYK
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Target
SYK
(Spleen tyrosine Kinase (SYK))
Alternative Name
syk (SYK Products )
Synonyms
p72-Syk antibody, Sykb antibody, p72syk antibody, spleen associated tyrosine kinase antibody, spleen tyrosine kinase antibody, syk antibody, SYK antibody, Syk antibody
Background
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C γ,dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion
Molecular Weight
72 kDa
Gene ID
6850
NCBI Accession
NP_001128524
UniProt
P43405
Pathways
Fc-epsilon Receptor Signaling Pathway , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Thromboxane A2 Receptor Signaling , BCR Signaling
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