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FGFR3 antibody (AA 630-680)
FGFR3
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC (p), IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FGFR3 Antibody
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Target
See all FGFR3 Antibodies
FGFR3
(Fibroblast Growth Factor Receptor 3 (FGFR3))
Binding Specificity
All epitopes for FGFR3 antibodies
AA 630-680
Reactivity
All reactivities for FGFR3 antibodies
Human, Mouse, Rat
Host
All hosts for FGFR3 antibodies
Rabbit
Clonality
All clonalities for FGFR3 antibodies
Polyclonal
Conjugate
All conjugates for FGFR3 antibodies
This FGFR3 antibody is un-conjugated
Application
All applications for FGFR3 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Specificity
FGFR3 antibody is human, mouse and rat reactive. At least three isoforms of FGFR3 are known to exist, this antibody will detect all three.
Purification
FGFR3 Antibody is affinity chromatography purified via peptide column.
Immunogen
FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3. The immunogen is located within amino acids 630 - 680 of FGFR3.
Isotype
IgG
Top Product
Discover our top product FGFR3 Primary Antibody
Alternatives
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Application Details
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Application Notes
FGF3 antibody can be used for detection of FGFR3 by Western blot at 1 - 2 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
FGFR3 Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
FGFR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for FGFR3
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Target
FGFR3
(Fibroblast Growth Factor Receptor 3 (FGFR3))
Alternative Name
FGFR3 (FGFR3 Products )
Synonyms
FGFR3 antibody, LOC100034114 antibody, ACH antibody, CD333 antibody, CEK2 antibody, HSFGFR3EX antibody, JTK4 antibody, FR3 antibody, Fgfr-3 antibody, Flg-2 antibody, HBGFR antibody, Mfr3 antibody, sam3 antibody, fc27h01 antibody, wu:fc27h01 antibody, fibroblast growth factor receptor 3 antibody, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog antibody, FGFR3 antibody, fgfr3.S antibody, Fgfr3 antibody, fgfr3 antibody
Background
FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1). It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2). It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5).
Molecular Weight
Predicted: 89 kDa Observed: 9+2, 98 kDa
Gene ID
2261
NCBI Accession
NP_001156685
UniProt
P22607
Pathways
RTK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Stem Cell Maintenance , Growth Factor Binding
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