ULK2 antibody (AA 480-530)

Catalog No. ABIN5690311

Product Details anti-ULK2 Antibody

Target: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Binding Specificity: AA 480-530

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least two isoforms of ULK2 are known to exist, this antibody will detect both isoforms. ULK2 antibody is predicted to not cross-react with ULK1.

Purification: ULK2 Antibody is affinity chromatography purified via peptide column.

Immunogen: ULK2 antibody was raised against a 17 amino acid peptide near the center of human ULK2 .

The immunogen is located within amino acids 480 - 530 of ULK2.

Isotype: IgG

Application Details

Application Notes: ULK2 Antibody can be used for detection of ULK2 by Western blot at 1 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ULK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: ULK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ULK2

Target: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Alternative Name: ULK2 (ULK2 Products)

Synonyms: ULK2 antibody, ATG1B antibody, Unc51.2 antibody, A830085I22Rik antibody, AU015340 antibody, mKIAA0623 antibody, unc-51 like autophagy activating kinase 2 antibody, unc-51 like kinase 2 antibody, ULK2 antibody, Ulk2 antibody, ulk2 antibody

Background: ULK2 Antibody: ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.

Molecular Weight: Predicted: 105, 114 kDa

Observed: 100 kDa

Gene ID: 9706

NCBI Accession: NP_055498

UniProt: Q8IYT8

Pathways: Regulation of Cell Size, Autophagy