ANKRD15 antibody
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- Target See all ANKRD15 Antibodies
- ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ANKRD15 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
- Immunogen
- KN motif and ankyrin repeat domains 1
- Isotype
- IgG
- Top Product
- Discover our top product ANKRD15 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04463( KANK1 Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))
- Alternative Name
- KANK1 (ANKRD15 Products)
- Synonyms
- ANKRD15 antibody, CPSQ2 antibody, KANK antibody, A930031B09Rik antibody, AU015049 antibody, AW121052 antibody, Ankrd15 antibody, D330024H06Rik antibody, mKIAA0172 antibody, KANK1 antibody, ankrd15 antibody, kank1.2 antibody, DMRT1 antibody, KN motif and ankyrin repeat domains 1 antibody, KN motif and ankyrin repeat domains 1 L homeolog antibody, doublesex and mab-3 related transcription factor 1 antibody, KANK1 antibody, Kank1 antibody, kank1.L antibody, DMRT1 antibody
- Background
- Synonyms:ANKRD15, KANK, KIAA0172 Background:Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity, the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia, the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading, the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.
- Molecular Weight
- 75-85 kDa,30 kDa
- Gene ID
- 23189
- UniProt
- Q14678
- Pathways
- Regulation of Actin Filament Polymerization
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