CNOT1 antibody
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- Target See all CNOT1 Antibodies
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CNOT1 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- CCR4-NOT transcription complex, subunit 1
- Isotype
- IgG
- Top Product
- Discover our top product CNOT1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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human brain tissue were subjected to SDS PAGE followed by western blot with FNab01805(CNOT1 antibody) at dilution of 1:800
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
- Alternative Name
- CNOT1 (CNOT1 Products)
- Synonyms
- CDC39 antibody, NOT1 antibody, NOT1H antibody, 6030411K04Rik antibody, AA815922 antibody, D830048B13 antibody, RGD1308009 antibody, GB18988 antibody, cdc39-like antibody, im:7141761 antibody, kiaa1007l antibody, wu:fc58h04 antibody, zgc:152902 antibody, CNOT1 antibody, not1 antibody, cdc39 antibody, not1h antibody, ad-005 antibody, NV18106 antibody, CCR4-NOT transcription complex subunit 1 antibody, CCR4-NOT transcription complex, subunit 1 antibody, CNOT1 antibody, Cnot1 antibody, LOC412371 antibody, cnot1 antibody, LOC100114396 antibody
- Background
- Synonyms:CDC39, KIAA1007, NOT1 Background:Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity.
- Molecular Weight
- 240-250 kDa,174 kDa
- Gene ID
- 23019
- UniProt
- A5YKK6
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
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