FURIN antibody
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- Target See all FURIN Antibodies
- FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FURIN antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA
- Immunogen
- furin (paired basic amino acid cleaving enzyme)
- Isotype
- IgG
- Top Product
- Discover our top product FURIN Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab03241( FURIN Antibody) at dilution of 1:600
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
- Alternative Name
- FURIN (FURIN Products)
- Synonyms
- FURIN antibody, furin antibody, si:dkey-281a24.5 antibody, FUR antibody, LOC100220259 antibody, PACE antibody, spc1 antibody, xfurin antibody, MGC82710 antibody, PCSK3 antibody, SPC1 antibody, 9130404I01Rik antibody, Fur antibody, Pcsk3 antibody, Pace antibody, furin, paired basic amino acid cleaving enzyme antibody, furin (paired basic amino acid cleaving enzyme) a antibody, furin (paired basic amino acid cleaving enzyme) b antibody, furin, paired basic amino acid cleaving enzyme L homeolog antibody, furin (paired basic amino acid cleaving enzyme) antibody, FURIN antibody, furina antibody, furinb antibody, furin antibody, furin.L antibody, Furin antibody
- Background
- Synonyms:FUR, PACE, PCSK3 Background:This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.
- Molecular Weight
- 90 kDa
- Gene ID
- 5045
- UniProt
- P09958
- Pathways
- Notch Signaling, Neurotrophin Signaling Pathway
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