SP1 antibody

Catalog No. ABIN5698476

Product Details anti-SP1 Antibody

Target: SP1 (Sp1 Transcription Factor (SP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Immunogen: Sp1 transcription factor

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08131(SP1 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for SP1

Target: SP1 (Sp1 Transcription Factor (SP1))

Alternative Name: SP1 (SP1 Products)

Synonyms: fc18h09 antibody, zgc:85950 antibody, wu:fc18h09 antibody, SP1 antibody, 1110003E12Rik antibody, AA450830 antibody, AI845540 antibody, Sp1-1 antibody, sp1 transcription factor antibody, Sp1 transcription factor antibody, Sp1 transcription factor L homeolog antibody, trans-acting transcription factor 1 antibody, sp1 antibody, SP1 antibody, Sp1 antibody, sp1.L antibody

Background: Synonyms:SP1, Sp1 transcription factor, Transcription factor Sp1, TSFP1 Background:Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications(phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene ID: 6667

UniProt: P08047

Pathways: Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction