DTX3L antibody

Catalog No. ABIN5698856

Product Details anti-DTX3L Antibody

Target: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DTX3L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: deltex 3-like (Drosophila)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for DTX3L

Target: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Alternative Name: DTX3L (DTX3L Products)

Synonyms: BBAP antibody, RGD1565144 antibody, AU042200 antibody, BC023741 antibody, DTX3L antibody, deltex E3 ubiquitin ligase 3L antibody, deltex 3-like, E3 ubiquitin ligase antibody, probable E3 ubiquitin-protein ligase DTX3 antibody, DTX3L antibody, Dtx3l antibody, LOC100521724 antibody

Background: Synonyms:BBAP Background:Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4(H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation(H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Molecular Weight: 84 kDa

Gene ID: 151636

UniProt: Q8TDB6

Pathways: Notch Signaling