INSIG2 antibody

Catalog No. ABIN5699473

Product Details anti-INSIG2 Antibody

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSIG2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: insulin induced gene 2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

rat liver tissue were subjected to SDS PAGE followed by western blot with FNab04334( INSIG2 Antibody) at dilution of 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for INSIG2

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Alternative Name: INSIG2 (INSIG2 Products)

Synonyms: MGC82156 antibody, INSIG-2 antibody, 2900053I11Rik antibody, C730043J18Rik antibody, Insig-2 antibody, insulin induced gene 2 antibody, insulin induced gene 2 L homeolog antibody, insig2 antibody, insig2.L antibody, INSIG2 antibody, Insig2 antibody

Background: Synonyms: Background:Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Molecular Weight: 30 kDa

Gene ID: 51141

UniProt: Q9Y5U4

Pathways: ER-Nucleus Signaling