CACNA1S antibody

Catalog No. ABIN5700411

Product Details anti-CACNA1S Antibody

Target: CACNA1S (Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1S antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Immunogen: calcium channel, voltage-dependent, L type, alpha 1S subunit

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab01173(CACNA1S antibody) at dilution of 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for CACNA1S

Target: CACNA1S (Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S))

Alternative Name: CACNA1S (CACNA1S Products)

Synonyms: CACNA1S antibody, cav1.1 antibody, ca(v)1.1 antibody, CACNL1A3 antibody, CCHL1A3 antibody, Cav1.1 antibody, HOKPP antibody, HOKPP1 antibody, MHS5 antibody, TTPP1 antibody, hypoPP antibody, AW493108 antibody, Cchl1a3 antibody, fmd antibody, mdg antibody, sj antibody, caV1.1 antibody, calcium voltage-gated channel subunit alpha1 S antibody, calcium channel, voltage-dependent, L type, alpha 1S subunit S homeolog antibody, calcium channel, voltage-dependent, L type, alpha 1S subunit antibody, CACNA1S antibody, cacna1s.S antibody, Cacna1s antibody

Background: Synonyms:CACH1, CACN1, CACNL1A3 Background:Voltage-sensitive calcium channels(VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting(L-type) calcium channels belong to the 'high-voltage activated'(HVA) group. They are blocked by dihydropyridines(DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA(omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA(omega-CTx-GVIA) and omega-agatoxin-IVA(omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

Molecular Weight: 200-220 kDa

Gene ID: 779

UniProt: Q13698

Pathways: Skeletal Muscle Fiber Development