EXOSC10 antibody

Catalog No. ABIN5702156

Product Details anti-EXOSC10 Antibody

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Immunogen: exosome component 10

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for EXOSC10

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Alternative Name: EXOSC10 (EXOSC10 Products)

Synonyms: Pmscl2 antibody, zgc:55695 antibody, pm-scl antibody, pm/scl-100 antibody, pmscl antibody, pmscl2 antibody, rrp6 antibody, rrp6p antibody, EXOSC10 antibody, 201.t00018 antibody, 21.m02990 antibody, DDBDRAFT_0203581 antibody, DDBDRAFT_0233752 antibody, DDB_0203581 antibody, DDB_0233752 antibody, PM-Scl antibody, PM/Scl-100 antibody, PMSCL antibody, PMSCL2 antibody, RRP6 antibody, Rrp6p antibody, p2 antibody, p3 antibody, p4 antibody, exosome component 10 antibody, 3'-5' exonuclease antibody, exosome component 10 L homeolog antibody, exosc10 antibody, EXOSC10 antibody, EHI_021400 antibody, BBOV_IV002650 antibody, CpipJ_CPIJ003896 antibody, CMU_031760 antibody, Tsp_05247 antibody, exosc10.L antibody, Exosc10 antibody

Background: Synonyms:PMSCL, PMSCL2, RRP6 Background:Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity(By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Gene ID: 5394

UniProt: Q01780