B-Cell Linker antibody
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- Target See all B-Cell Linker (BLNK) Antibodies
- B-Cell Linker (BLNK)
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This B-Cell Linker antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- B-cell linker
- Isotype
- IgG
- Top Product
- Discover our top product BLNK Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Raji cells were subjected to SDS PAGE followed by western blot with FNab00908( BLNK Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- B-Cell Linker (BLNK)
- Alternative Name
- BLNK (BLNK Products)
- Synonyms
- BLNK antibody, blnk antibody, MGC147045 antibody, BASH antibody, Bca antibody, Ly-57 antibody, Ly57 antibody, Lyw-57 antibody, SLP-65 antibody, AGM4 antibody, BLNK-S antibody, LY57 antibody, SLP65 antibody, bca antibody, B-cell linker antibody, B cell linker antibody, BLNK antibody, blnk antibody, Blnk antibody
- Background
- Synonyms:BASH, SLP65 Background:Functions as a central linker protein, downstream of the B-cell receptor(BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3(PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
- Molecular Weight
- 68 kDa, 70 kDa
- Gene ID
- 29760
- UniProt
- Q8WV28
- Pathways
- BCR Signaling
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