TSEN2 antibody
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- Target See all TSEN2 Antibodies
- TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TSEN2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Immunogen
- tRNA splicing endonuclease 2 homolog (S. cerevisiae)
- Isotype
- IgG
- Top Product
- Discover our top product TSEN2 Primary Antibody
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- Application Notes
- WB:1:500-1:5000
- Comment
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human brain tissue were subjected to SDS PAGE followed by western blot with FNab09038(TSEN2 antibody) at dilution of 1:400
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
- Alternative Name
- TSEN2 (TSEN2 Products)
- Synonyms
- AU067695 antibody, RGD1309946 antibody, PCH2B antibody, SEN2 antibody, SEN2L antibody, tRNA splicing endonuclease subunit 2 antibody, TSEN2 antibody, Tsen2 antibody
- Background
- Synonyms:HsSen2, PCH2B, SEN2, SEN2L, tRNA intron endonuclease Sen2, TSEN2 Background:Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'-and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
- Molecular Weight
- 45kDa
- Gene ID
- 80746
- UniProt
- Q8NCE0
- Pathways
- Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha
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