KANK2 antibody

Catalog No. ABIN5703454

Product Details anti-KANK2 Antibody

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KANK2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: KN motif and ankyrin repeat domains 2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for KANK2

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Alternative Name: KANK2 (KANK2 Products)

Synonyms: ANKRD25 antibody, MXRA3 antibody, SIP antibody, AI504612 antibody, Ankrd25 antibody, BC010245 antibody, KN motif and ankyrin repeat domains 2 antibody, KANK2 antibody, Kank2 antibody

Background: Synonyms:ANKRD25, KIAA1518, MXRA3, SIP Background:Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm, the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway(PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis, proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus(PubMed:22371500). May be involved in promotion of cell proliferation(By similarity).

Gene ID: 25959

UniProt: Q63ZY3