YTHDF2 antibody
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- Target See all YTHDF2 Antibodies
- YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This YTHDF2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogen
- YTH domain family, member 2
- Isotype
- IgG
- Top Product
- Discover our top product YTHDF2 Primary Antibody
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- Application Notes
- WB:1:500-1:5000,IF:1:10-1:100,IP:1:200-1:2000,IHC:1:20-1:200
- Comment
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09573( YTHDF2 Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))
- Alternative Name
- YTHDF2 (YTHDF2 Products)
- Synonyms
- MGC82537 antibody, HGRG8 antibody, NY-REN-2 antibody, YTH N(6)-methyladenosine RNA binding protein 2 L homeolog antibody, YTH N6-methyladenosine RNA binding protein 2 antibody, ythdf2.L antibody, YTHDF2 antibody
- Background
- Synonyms:CLL associated antigen KW 14, HGRG8, NY REN 2, YTH domain family protein 2, YTH domain family, member 2, YTHDF2 Background:Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, and regulates mRNA stability(PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies(P-bodies), leading to mRNA degradation(PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation(PubMed:26458103).
- Molecular Weight
- 61kDa
- Gene ID
- 51441
- UniProt
- Q9Y5A9
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