CLP1 antibody

Catalog No. ABIN5705383

Product Details anti-CLP1 Antibody

Target: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for CLP1

Target: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Alternative Name: CLP1 (CLP1 Products)

Synonyms: Heab antibody, RGD1307679 antibody, AI462438 antibody, ACDP1 antibody, CLP-1 antibody, CGP-39 antibody, GP-39 antibody, SPC-40 antibody, SPS-40 antibody, YKL-40 antibody, HEAB antibody, hClp1 antibody, fa28a12 antibody, wu:fa28a12 antibody, clp1 antibody, cleavage and polyadenylation factor I subunit 1 antibody, CLP1, cleavage and polyadenylation factor I subunit antibody, cyclin and CBS domain divalent metal cation transport mediator 1 antibody, chitinase 3-like 1 (cartilage glycoprotein-39) antibody, cleavage and polyadenylation factor I subunit 1 L homeolog antibody, Clp1 antibody, CNNM1 antibody, CHI3L1 antibody, CLP1 antibody, clp1 antibody, clp1.L antibody

Background: Synonyms:HEAB Background:Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA(dsRNA), single-stranded RNA(ssRNA), double-stranded DNA(dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing, this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA(PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development(PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II(CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs(siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex(RISC). However, endogenous siRNAs and microRNAs(miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Molecular Weight: 48 kDa

Gene ID: 10978

UniProt: Q92989

Pathways: Ribonucleoprotein Complex Subunit Organization