ADAM17 antibody (AA 811-824)

Catalog No. ABIN574362

Product Details anti-ADAM17 Antibody

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Binding Specificity: AA 811-824

Reactivity: Human, Cow, Monkey, Bat, Chicken

Host: Goat

Clonality: Polyclonal

Conjugate: This ADAM17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Brand: IHC-plus™

Specificity: Human ADAM17. This antibody is expected to recognise isoform 1 (represented by NP_003174) and not isoform 2 (represented by NP_068604).

Predicted Reactivity: Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Elephant, Bat, Bovine, Turkey, Sparrow, Chicken, Platypus (100%) Gibbon, Mouse, Rat, Hamster, Panda, Dog, Horse, Pig, Opossum, Lizard, Xenopus (93%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide LQRQNRVDSKETEC from the C-terminus of human ADAM17 (NP_003174.3). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Elephant, Bat, Bovine, Turkey, Sparrow, Chicken, Platypus (100%), Gibbon, Mouse, Rat, Hamster, Panda, Dog, Horse, Pig, Opossum, Lizard, Xenopus (93%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: IHC, IHC-P (3.75 μg/mL), Peptide-ELISA (1:128000), WB (0.1 - 0.3 μg/mL)

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Alternative Name: ADAM17 / TACE (ADAM17 Products)

Synonyms: ADAM18 antibody, CD156B antibody, CSVP antibody, NISBD antibody, TACE antibody, CD156b antibody, Tace antibody, adam17 antibody, si:dkey-81b15.2 antibody, adam18 antibody, cd156b antibody, csvp antibody, tace antibody, fc20b01 antibody, wu:fc20b01 antibody, zgc:63886 antibody, ADAM metallopeptidase domain 17 antibody, a disintegrin and metallopeptidase domain 17 antibody, ADAM metallopeptidase domain 17b antibody, ADAM metallopeptidase domain 17 L homeolog antibody, ADAM metallopeptidase domain 17a antibody, ADAM17 antibody, Adam17 antibody, adam17b antibody, adam17.L antibody, adam17a antibody

Background: Name/Gene ID: ADAM17
Subfamily: Metallopeptidase M12B
Family: Protease

Synonyms: ADAM17, CD156B, CD156b antigen, CSVP, ADAM 17, NISBD, TNF-alpha converting enzyme, TNF-alpha convertase, TNF-alpha-converting enzyme, Snake venom-like protease, TACE

Gene ID: 6868

NCBI Accession: NP_003174

UniProt: P78536

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus