NFKBIB antibody

Catalog No. ABIN5959588

Product Details anti-NFKBIB Antibody

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This NFKBIB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: I kappa B beta,I-kappa-B-beta,IkappaBbeta,IKB beta,IkB-B,IkB-beta,IKBB,IKBB,IkBbeta,NF kappa BIB,NF-kappa-B inhibitor beta,NF-kappa-BIB,Nfkbib,Thyroid receptor interacting protein 9,Thyroid receptor-interacting protein 9,TR interacting protein 9,TR-interacting protein 9,TRIP-9,TRIP9

Purification: Protein A purification

Immunogen: Recombinant Protein

Clone: 0

Isotype: IgG

Application Details

Application Notes: IHC 1:100-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NFKBIB

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Alternative Name: NFKBIB (NFKBIB Products)

Synonyms: NFKBIB antibody, IKB-beta antibody, IKappaBbeta antibody, IkB antibody, IkBb antibody, IKBB antibody, TRIP9 antibody, NFKB inhibitor beta antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta antibody, NFKBIB antibody, Nfkbib antibody

Background: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Gene ID: 4793

UniProt: Q15653

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades