ESR2 antibody (pSer105)

Catalog No. ABIN5960540

Product Details anti-ESR2 Antibody

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Binding Specificity: pSer105

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: ER BETA,ER-beta,Erb,ESR B,ESR BETA,ESR2,ESR2,ESRB,ESTRB,estrogen nuclear receptor beta variant a,estrogen nuclear receptor beta variant b,estrogen receptor 2 (ER beta),Estrogen receptor 2,estrogen receptor beta 4,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human ERbeta around the phosphorylation site of Ser105

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:5000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ESR2

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Alternative Name: ERbeta (ESR2 Products)

Synonyms: ER-BETA antibody, ESR-BETA antibody, ESRB antibody, ESTRB antibody, Erb antibody, NR3A2 antibody, ER[b]1 antibody, zfER-beta1 antibody, zfER[b]1 antibody, erb2 antibody, CERB antibody, ERB antibody, erb antibody, esrb antibody, estrb antibody, nr3a2 antibody, ERbeta antibody, er-beta antibody, esr-beta antibody, ESR2 antibody, ERBETA antibody, er antibody, ER-beta antibody, ER[b] antibody, Estrb antibody, ER[b]2 antibody, ER[b]a antibody, zfER[b]2 antibody, zfER-beta2 antibody, Erb2 antibody, esr2 antibody, erbeta antibody, Esr2 antibody, ERBeta2 antibody, estrogen receptor 2 antibody, estrogen receptor 2b antibody, estrogen receptor beta 2 antibody, estrogen receptor 2 (beta) antibody, estrogen receptor 2a antibody, estrogen receptor beta antibody, ESR2 antibody, esr2b antibody, erb2 antibody, esr2 antibody, Esr2 antibody, esr2a antibody, erbeta antibody

Background: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Molecular Weight: 59kDa

Gene ID: 2100

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling