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Src antibody (pTyr529)
Src
Reactivity: Human, Mouse, Rat, Monkey
WB, ELISA, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Src Antibody
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Target
See all Src Antibodies
Src
(Proto-oncogene tyrosine-protein kinase Src (Src))
Binding Specificity
All epitopes for Src antibodies
pTyr529
Reactivity
All reactivities for Src antibodies
Human, Mouse, Rat, Monkey
Host
All hosts for Src antibodies
Rabbit
Clonality
All clonalities for Src antibodies
Polyclonal
Conjugate
All conjugates for Src antibodies
This Src antibody is un-conjugated
Application
All applications for Src antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
ASV,Avian sarcoma virus,c SRC,CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA,cSrc,EC 2.7.10.2,Neuronal CSRC tyrosine specific protein kinase,Neuronal SRC,Oncogene SRC,OTTHUMP00000174476,OTTHUMP00000174477,p60 Src,p60-Src,p60Src,pp60c src,pp60c-src,pp60csrc,Proto oncogene tyrosine protein kinase Src,Proto-oncogene c-Src,Proto-oncogene tyrosine-protein kinase Src,Protooncogene SRC,Protooncogene SRC Rous sarcoma,Src,SRC Oncogene,SRC proto oncogene non receptor tyrosine kinase,SRC,SRC1,Tyrosine kinase pp60c src,Tyrosine protein kinase SRC 1,Tyrosine protein kinase SRC1,v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog,V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian),v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian
Purification
Affinity purification
Immunogen
Synthesized peptide derived from human c-Src around the phosphorylation site of Tyr529
Isotype
IgG
Top Product
Discover our top product Src Primary Antibody
Alternatives
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Application Details
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Application Notes
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Restrictions
For Research Use only
Handling
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Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for Src
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Target
Src
(Proto-oncogene tyrosine-protein kinase Src (Src))
Alternative Name
c-Src (Src Products )
Synonyms
AW259666 antibody, pp60c-src antibody, C-src1 antibody, CG7524 antibody, D-Src64B antibody, D-src antibody, DSRC64 antibody, DSrc antibody, DSrc64 antibody, DSrc64B antibody, Dm SRC1 antibody, DmHD-358 antibody, Dmel\CG7524 antibody, Dsrc antibody, Dsrc64 antibody, Dsrc64B antibody, HD-358 antibody, MRE5 antibody, SRC 64B antibody, Src antibody, Src1 antibody, Src64 antibody, c-src antibody, dSrc antibody, dsrc antibody, src antibody, src1 antibody, src64 antibody, src64B antibody, src64b antibody, ASV antibody, SRC1 antibody, c-SRC antibody, p60-Src antibody, c-Src antibody, PP60C-SCR antibody, SDR antibody, SRC proto-oncogene, non-receptor tyrosine kinase antibody, uncharacterized LOC5574802 antibody, proto-oncogene tyrosine-protein kinase src antibody, Rous sarcoma oncogene antibody, Src oncogene at 64B antibody, SRC antibody, LOC5574802 antibody, CpipJ_CPIJ010659 antibody, Src antibody, Src64B antibody
Target Type
Viral Protein
Background
Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
Molecular Weight
60kDa
Gene ID
6714
UniProt
P12931
Pathways
JAK-STAT Signaling , Neurotrophin Signaling Pathway , Intracellular Steroid Hormone Receptor Signaling Pathway , Regulation of Intracellular Steroid Hormone Receptor Signaling , Cellular Response to Molecule of Bacterial Origin , Cell-Cell Junction Organization , Regulation of Carbohydrate Metabolic Process , Autophagy , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Smooth Muscle Cell Migration , Negative Regulation of intrinsic apoptotic Signaling , Platelet-derived growth Factor Receptor Signaling , Thromboxane A2 Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling
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