AFT1 antibody
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- Target See all AFT1 Antibodies
- AFT1 (Activating Transcription Factor 1 (AFT1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AFT1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human ATF1
- Isotype
- IgG
- Top Product
- Discover our top product AFT1 Primary Antibody
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- Application Notes
- WB 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- AFT1 (Activating Transcription Factor 1 (AFT1))
- Alternative Name
- ATF1 (AFT1 Products)
- Synonyms
- ews-atf1 antibody, fus/atf-1 antibody, treb36 antibody, ATF1 antibody, EWS-ATF1 antibody, FUS/ATF-1 antibody, TREB36 antibody, Atf-1 antibody, wu:fc92c07 antibody, zgc:64099 antibody, activating transcription factor 1 antibody, activating transcription factor 1 L homeolog antibody, atf1 antibody, ATF1 antibody, MGC85066 antibody, atf1.L antibody, Atf1 antibody
- Background
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Synonyms: Activating transcription factor 1,ATF 1,atf1,ATF1 EWS fusion gene,ATF1 FUS fusion gene,ATF1,cAMP dependent transcription factor 1,cAMP-dependent transcription factor ATF-1,Cyclic AMP dependent transcription factor ATF 1,Cyclic AMP dependent transcription factor ATF1,Cyclic AMP-dependent transcription factor ATF-1,EWS AFT1,FUS ATF 1,FUS/ATF 1,Protein TREB36,RNA binding protein activating transcription factor 1 fusion protein,TREB 36,TREB36,TREB36 protein
Background: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
- Molecular Weight
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Observed_MW: 27-36kDa
Calculated_MW: 15kDa/29kDa
- Gene ID
- 466
- UniProt
- P18846
- Pathways
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades
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