OPTN antibody

Catalog No. ABIN5963871

Product Details anti-OPTN Antibody

Target: OPTN (Optineurin (OPTN))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPTN antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human OPTN

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for OPTN

Target: OPTN (Optineurin (OPTN))

Alternative Name: OPTN (OPTN Products)

Synonyms: nrp antibody, fip2 antibody, hip7 antibody, hypl antibody, glc1e antibody, tfiiia-intp antibody, ALS12 antibody, FIP2 antibody, GLC1E antibody, HIP7 antibody, HYPL antibody, NRP antibody, TFIIIA-INTP antibody, Fip2 antibody, 4930441O07Rik antibody, fj52f04 antibody, si:ch211-240l19.3 antibody, wu:fj52f04 antibody, zgc:66386 antibody, zgc:77868 antibody, optineurin antibody, optineurin L homeolog antibody, OPTN antibody, optn antibody, Optn antibody, optn.L antibody

Background:

Synonyms: 14.7K interacting protein,Ag9 C5,ALS12,E3 14.7K interacting protein,E3-14.7K-interacting protein,FIP 2,FIP-2,FIP2,Glaucoma 1 open angle E (adult onset),Glaucoma 1 open angle E,GLC1E,HIP 7,HIP-7,HIP7,Huntingtin interacting protein 7,Huntingtin interacting protein HYPL,Huntingtin interacting protein L,Huntingtin yeast partner L,Huntingtin-interacting protein 7,Huntingtin-interacting protein L,HYPL,Injury inducible protein I 55,NEMO related protein,NEMO-related protein,NRP,Optic neuropathy inducing protein,Optic neuropathy-inducing protein,Optineurin,OPTN,OPTN,TFIIIA IntP,TFIIIA-IntP,Transcription factor IIIA interacting protein,Transcription factor IIIA-interacting protein,Tumor necrosis factor alpha inducible cellular protein containing leucine zipper domains

Background: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Molecular Weight:

Observed_MW: 78kDa

Calculated_MW: 59kDa/65kDa

Gene ID: 10133

UniProt: Q96CV9

Pathways: M Phase