SIRPA antibody

Catalog No. ABIN5965376

Product Details anti-SIRPA Antibody

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRPA antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human SIRPA

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Alternative Name: SIRPA (SIRPA Products)

Synonyms: BIT antibody, CD172A antibody, MFR antibody, MYD-1 antibody, P84 antibody, PTPNS1 antibody, SHPS1 antibody, SIRP antibody, SIRPA antibody, SIRP-A1 antibody, SIRP-B1 antibody, AI835480 antibody, Bit antibody, CD172a antibody, Ptpns1 antibody, SHP-1 antibody, SHPS-1 antibody, swc3 antibody, signal regulatory protein alpha antibody, myeloperoxidase antibody, signal-regulatory protein alpha antibody, tyrosine-protein phosphatase non-receptor type substrate 1 antibody, SIRPA antibody, MPO antibody, LOC458039 antibody, LOC100400378 antibody, LOC100590224 antibody, Sirpa antibody

Background:

Synonyms: Signal regulatory protein alpha type 1,Bit,Brain Ig like molecule with tyrosine based activation motifs,Brain Ig-like molecule with tyrosine-based activation motifs,Brain immunoglobulin like molecule with tyrosine based activation motifs,CD172 antigen like family member A,CD172 antigen-like family member A,CD172a,CD172a antigen,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MFR,MYD 1,Myd 1 antigen,MyD-1 antigen,p84,Protein tyrosine phosphatase non receptor type substrate 1,PTPNS1,SHP substrate 1,SHPS-1,SHPS1,SHPS1,Signal regulatory protein alpha 2,Signal regulatory protein alpha 3,Signal regulatory protein alpha,Signal regulatory protein alpha type 2,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,Signal-regulatory protein alpha-3,SIRP,Sirp-alpha-1,Sirp-alpha-2,Sirp-alpha-3,SIRPA,SIRPalpha,SIRPalpha1,SIRPalpha2,SIRPalpha3,Tyrosine phosphatase SHP substrate 1,Tyrosine protein phosphatase non receptor type substrate 1,Tyrosine-protein phosphatase non-receptor type substrate 1

Background: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Molecular Weight:

Observed_MW: 120kDa

Calculated_MW: 54kDa/55kDa

Gene ID: 140885

UniProt: P78324