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PNP antibody (AA 1-289)
NP
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PNP Antibody
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Target
See all PNP (NP) Antibodies
PNP (NP)
(Nucleoside Phosphorylase (NP))
Binding Specificity
All epitopes for PNP antibodies
AA 1-289
Reactivity
All reactivities for PNP antibodies
Human
Host
All hosts for PNP antibodies
Rabbit
Clonality
All clonalities for PNP antibodies
Polyclonal
Conjugate
All conjugates for PNP antibodies
This PNP antibody is un-conjugated
Application
All applications for PNP antibodies
Western Blotting (WB)
Sequence
MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS
Cross-Reactivity
Human, Mouse
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human PNP (NP_000261.2).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for PNP
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Target
PNP (NP)
(Nucleoside Phosphorylase (NP))
Alternative Name
PNP (NP Products )
Synonyms
NP antibody, PRO1837 antibody, PUNP antibody, Np antibody, AL024301 antibody, AU015798 antibody, Np-1 antibody, Np-2 antibody, Pnp1 antibody, purine nucleoside phosphorylase antibody, purine-nucleoside phosphorylase antibody, PNP antibody, Pnp antibody
Target Type
Viral Protein
Background
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.,PNP,NP,PRO1837,PUNP,Neuroscience,Neurodegenerative Diseases,PNP
Molecular Weight
32 kDa
Gene ID
4860
UniProt
P00491
Pathways
Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Ribonucleoside Biosynthetic Process , Positive Regulation of Response to DNA Damage Stimulus
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