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NRF2 antibody (AA 366-605)
NFE2L2
Reactivity: Human
WB, IHC, IF, IP
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NRF2 Antibody
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Target
See all NRF2 (NFE2L2) Antibodies
NRF2 (NFE2L2)
(Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
Binding Specificity
All epitopes for NRF2 antibodies
AA 366-605
Reactivity
All reactivities for NRF2 antibodies
Human
Host
All hosts for NRF2 antibodies
Rabbit
Clonality
All clonalities for NRF2 antibodies
Polyclonal
Conjugate
All conjugates for NRF2 antibodies
This NRF2 antibody is un-conjugated
Application
All applications for NRF2 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
Sequence
YGDTLLGLSD SEVEELDSAP GSVKQNGPKT PVHSSGDMVQ PLSPSQGQST HVHDAQCENT PEKELPVSPG HRKTPFTKDK HSSRLEAHLT RDELRAKALH IPFPVEKIIN LPVVDFNEMM SKEQFNEAQL ALIRDIRRRG KNKVAAQNCR KRKLENIVEL EQDLDHLKDE KEKLLKEKGE NDKSLHLLKK QLSTLYLEVF SMLRDEDGKP YSPSEYSLQQ TRDGNVFLVP KSKKPDVKKN
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 366-605 of human NRF2 (NP_006155.2).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
References for anti-NRF2 antibody (ABIN6144560)
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Chen, Li, Fan, Cao, Yao, Xu : "Selenium antagonizes cadmium-induced apoptosis in chicken spleen but not involving Nrf2-regulated antioxidant response. " in: Ecotoxicology and environmental safety , Vol. 145 , pp. 503-510 , (2017 ) (PubMed ).
Target Details for NRF2
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Target
NRF2 (NFE2L2)
(Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
Alternative Name
NFE2L2 (NFE2L2 Products )
Synonyms
Nrf2 antibody, nfe2l2 antibody, wu:fc15g09 antibody, wu:fj67e03 antibody, NF-E2R2 antibody, NRF2 antibody, AI194320 antibody, nuclear factor, erythroid 2-like 2a antibody, nuclear factor, erythroid 2 like 2 S homeolog antibody, nuclear factor, erythroid 2 like 2 antibody, nuclear factor, erythroid derived 2, like 2 antibody, nuclear factor, erythroid 2-like 2 antibody, nfe2l2a antibody, nfe2l2.S antibody, NFE2L2 antibody, Nfe2l2 antibody
Background
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters, many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene.,NFE2L2,HEBP1,NRF2,Epigenetics & Nuclear Signaling,Transcription Factors,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial Biogenesis,Nucleotide metabolism,Molecular processes,Cardiovascular,Heart,Cardiac metabolism,NFE2L2
Molecular Weight
65 kDa/66 kDa/67 kDa
Gene ID
4780
UniProt
Q16236
Pathways
ER-Nucleus Signaling , Negative Regulation of intrinsic apoptotic Signaling
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