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EFCAB4B antibody (AA 1-200)
EFCAB4B
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-EFCAB4B Antibody
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Target
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EFCAB4B
(EF-Hand Calcium Binding Domain 4B (EFCAB4B))
Binding Specificity
All epitopes for EFCAB4B antibodies
AA 1-200
Reactivity
All reactivities for EFCAB4B antibodies
Human
Host
All hosts for EFCAB4B antibodies
Rabbit
Clonality
All clonalities for EFCAB4B antibodies
Polyclonal
Conjugate
All conjugates for EFCAB4B antibodies
This EFCAB4B antibody is un-conjugated
Application
All applications for EFCAB4B antibodies
Western Blotting (WB)
Sequence
MAAPDGRVVS RPQRLGQGSG QGPKGSGACL HPLDSLEQKE TQEQTSGQLV MLRKAQEFFQ TCDAEGKGFI ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ NNPSQEDAGE QVAQRHEEKV YLSRGDEDLG DMGEDEEAQF RMLMDRLGAQ KVLEDESDVK QLWLQLKKEE PHLLSNFEDF
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Purification
Affinity purification
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CRACR2A (NP_001138430.1).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for EFCAB4B
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Target
EFCAB4B
(EF-Hand Calcium Binding Domain 4B (EFCAB4B))
Alternative Name
CRACR2A (EFCAB4B Products )
Synonyms
CRACR2A antibody, Gm1073 antibody, Gm462 antibody, calcium release activated channel regulator 2A antibody, CRACR2A antibody, Cracr2a antibody
Background
[Isoform 1]: Ca(2+-binding protein that plays a key role in store-operated Ca(2+ entry (SOCE in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.,CRACR2A,EFCAB4B,Signal Transduction,Neuroscience,Calcium Signaling,CRACR2A
Molecular Weight
45 kDa/83 kDa
Gene ID
84766
UniProt
Q9BSW2
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