herpud1-a antibody, herp antibody, herpud1 antibody, mif1 antibody, sup antibody, HERPUD1 antibody, zgc:114134 antibody, HERP antibody, Mif1 antibody, SUP antibody, Herp antibody, Mifl antibody, Sup antibody, homocysteine inducible ER protein with ubiquitin like domain 1 S homeolog antibody, homocysteine inducible ER protein with ubiquitin like domain 1 L homeolog antibody, homocysteine inducible ER protein with ubiquitin like domain 1 antibody, homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 antibody, herpud1.S antibody, herpud1.L antibody, herpud1 antibody, HERPUD1 antibody, Herpud1 antibody
Background
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.,HERPUD1,HERP,Mif1,SUP,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,HERPUD1