KIR2DL4/CD158d antibody (AA 22-242)
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- Target See all KIR2DL4/CD158d (KIR2DL4) Antibodies
- KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
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Binding Specificity
- AA 22-242
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KIR2DL4/CD158d antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- WAHVGGQDKP FCSAWPSAVV PQGGHVTLRC HYRRGFNIFT LYKKDGVPVP ELYNRIFWNS FLISPVTPAH AGTYRCRGFH PHSPTEWSAP SNPLVIMVTG LYEKPSLTAR PGPTVRAGEN VTLSCSSQSS FDIYHLSREG EAHELRLPAV PSINGTFQAD FPLGPATHGE TYRCFGSFHG SPYEWSDPSD PLPVSVTGNP SSSWPSPTEP SFKTGIARHL H
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human KIR2DL4 (NP_002246.5).
- Isotype
- IgG
- Top Product
- Discover our top product KIR2DL4 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
- Alternative Name
- KIR2DL4 (KIR2DL4 Products)
- Synonyms
- G9P antibody, CD158D antibody, KIR103 antibody, KIR103AS antibody, KIR2DL4 antibody, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 antibody, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 antibody, KIR2DL4 antibody
- Background
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly.,KIR2DL4,CD158D,G9P,KIR-103AS,KIR-2DL4,KIR103,KIR103AS,Immunology & Inflammation,CD markers,Cell Intrinsic Innate Immunity Signaling Pathway,KIR2DL4
- Molecular Weight
- 24 kDa/33 kDa/35 kDa/37 kDa/39 kDa/41 kDa
- Gene ID
- 3805
- UniProt
- Q99706
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