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Mesothelin antibody (AA 37-296)
MSLN
Reactivity: Human
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Mesothelin Antibody
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Target
See all Mesothelin (MSLN) Antibodies
Mesothelin (MSLN)
Binding Specificity
All epitopes for Mesothelin antibodies
AA 37-296
Reactivity
All reactivities for Mesothelin antibodies
Human
Host
All hosts for Mesothelin antibodies
Rabbit
Clonality
All clonalities for Mesothelin antibodies
Polyclonal
Conjugate
All conjugates for Mesothelin antibodies
This Mesothelin antibody is un-conjugated
Application
All applications for Mesothelin antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Sequence
LAGETGQEAA PLDGVLANPP NISSLSPRQL LGFPCAEVSG LSTERVRELA VALAQKNVKL STEQLRCLAH RLSEPPEDLD ALPLDLLLFL NPDAFSGPQA CTRFFSRITK ANVDLLPRGA PERQRLLPAA LACWGVRGSL LSEADVRALG GLACDLPGRF VAESAEVLLP RLVSCPGPLD QDQQEAARAA LQGGGPPYGP PSTWSVSTMD ALRGLLPVLG QPIIRSIPQG IVAAWRQRSS RDPSWRQPER TILRPRFRRE
Cross-Reactivity
Human, Rat
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 37-296 of human MSLN (NP_001170826.1).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000,IHC,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for Mesothelin
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Target
Mesothelin (MSLN)
Alternative Name
MSLN (MSLN Products )
Synonyms
MPF antibody, SMRP antibody, MSLN antibody, mesothelin antibody, MSLN antibody, Msln antibody, LOC611363 antibody, LOC100524016 antibody
Background
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.,MSLN,MPF,SMRP,Cancer,Tumor immunology,Tumor-associated antigens,Tumor biomarkers,Immunology & Inflammation,MSLN
Molecular Weight
67 kDa/68 kDa/71 kDa
Gene ID
10232
UniProt
Q13421
Pathways
EGFR Signaling Pathway , Positive Regulation of Peptide Hormone Secretion , Intracellular Steroid Hormone Receptor Signaling Pathway , Steroid Hormone Mediated Signaling Pathway , Carbohydrate Homeostasis , cAMP Metabolic Process , Regulation of G-Protein Coupled Receptor Protein Signaling , Positive Regulation of Endopeptidase Activity , Regulation of Carbohydrate Metabolic Process
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