D22S673 antibody, HC2 antibody, HCF2 antibody, HCII antibody, HLS2 antibody, LS2 antibody, THPH10 antibody, serpind1 antibody, MGC53936 antibody, rls2var1 antibody, AA985900 antibody, AI303446 antibody, Hcf2 antibody, serpin family D member 1 antibody, serpin peptidase inhibitor, clade D (heparin cofactor), member 1 L homeolog antibody, serpin peptidase inhibitor, clade D (heparin cofactor), member 1 antibody, serine (or cysteine) peptidase inhibitor, clade D, member 1 antibody, SERPIND1 antibody, serpind1.L antibody, Serpind1 antibody, serpind1 antibody
Background
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.,SERPIND1,D22S673,HC2,HCF2,HCII,HLS2,LS2,THPH10,Cardiovascular,Blood,SERPIND1