UQCRFS1 antibody (AA 79-274)
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- Target See all UQCRFS1 Antibodies
- UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))
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Binding Specificity
- AA 79-274
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This UQCRFS1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- SHTDIKVPDF SEYRRLEVLD STKSSRESSE ARKGFSYLVT GVTTVGVAYA AKNAVTQFVS SMSASADVLA LAKIEIKLSD IPEGKNMAFK WRGKPLFVRH RTQKEIEQEA AVELSQLRDP QHDLDRVKKP EWVILIGVCT HLGCVPIANA GDFGGYYCPC HGSHYDASGR IRLGPAPLNL EVPTYEFTSD DMVIVG
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 79-274 of human UQCRFS1 (NP_005994.2).
- Isotype
- IgG
- Top Product
- Discover our top product UQCRFS1 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells." in: The international journal of biochemistry & cell biology, Vol. 89, pp. 42-56, (2017) (PubMed).
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Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells." in: The international journal of biochemistry & cell biology, Vol. 89, pp. 42-56, (2017) (PubMed).
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- Target
- UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))
- Alternative Name
- UQCRFS1 (UQCRFS1 Products)
- Synonyms
- uqcrfs1 antibody, MGC53134 antibody, rip1 antibody, ris1 antibody, risp antibody, uqcr5 antibody, fb78f10 antibody, wu:fb05d11 antibody, wu:fb78f10 antibody, wu:fj05e12 antibody, zgc:73109 antibody, zgc:85614 antibody, GLEAN_00043 antibody, RIP1 antibody, RIS1 antibody, RISP antibody, UQCR5 antibody, 4430402G14Rik antibody, AI875505 antibody, LRRGT00195 antibody, UQCRFSL1 antibody, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 S homeolog antibody, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 antibody, cytochrome b-c1 complex subunit Rieske, mitochondrial antibody, iron-sulfur protein 1 antibody, uqcrfs1.S antibody, uqcrfs1 antibody, LOC661125 antibody, LOC705178 antibody, UQCRFS1 antibody, Uqcrfs1 antibody, LOC100227575 antibody, isp1 antibody
- Background
- [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII, ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII and cytochrome c oxidase (complex IV, CIV, that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0 site in cytochrome b to cytochrome c1 (By similarity. Incorporation of UQCRFS1 is the penultimate step in complex III assembly.,UQCRFS1,RIP1,RIS1,RISP,UQCR5,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Oxidative phosphorylation,Neuroscience,Neurodegenerative Diseases,UQCRFS1
- Molecular Weight
- 29 kDa
- Gene ID
- 7386
- UniProt
- P47985
- Pathways
- Proton Transport
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