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IL1RAP antibody (AA 484-518)

IL1RAP Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB57769 unconjugated
Catalog No. ABIN6242410
  • Target See all IL1RAP Antibodies
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    Binding Specificity
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 484-518
    Reactivity
    • 30
    • 12
    • 3
    Human, Mouse
    Host
    • 33
    • 4
    Rabbit
    Clonality
    • 33
    • 4
    Polyclonal
    Conjugate
    • 25
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL1RAP antibody is un-conjugated
    Application
    • 24
    • 12
    • 10
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    H
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 484-518 amino acids of human IL1RAP.
    Clone
    RB57769
    Isotype
    IgG
    Top Product
    Discover our top product IL1RAP Primary Antibody
  • Application Notes
    WB: 1:2000. IHC-P: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    Alternative Name
    IL1RAP (IL1RAP Products)
    Synonyms
    IL1RAP antibody, il-1racp antibody, il-racp antibody, il1r3 antibody, C3orf13 antibody, IL-1RAcP antibody, IL1R3 antibody, 6430709H04Rik antibody, AI255955 antibody, AV239853 antibody, IL-1RAcp antibody, Il1racpb antibody, interleukin 1 receptor accessory protein antibody, IL1RAP antibody, il1rap antibody, il-1racp antibody, Il1rap antibody
    Background
    Coreceptor for IL1RL2 in the IL-36 signaling system (,By similarity),. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
    Molecular Weight
    65418
    UniProt
    Q9NPH3
    Pathways
    NF-kappaB Signaling, Growth Factor Binding
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