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Transferrin Receptor antibody (AA 649-677)
TFRC
Reactivity: Human
WB
Host: Mouse
Monoclonal
514CT23-4-1
unconjugated
Product Details anti-Transferrin Receptor Antibody
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Target
See all Transferrin Receptor (TFRC) Antibodies
Transferrin Receptor (TFRC)
(Transferrin Receptor (p90, CD71) (TFRC))
Binding Specificity
All epitopes for Transferrin Receptor antibodies
AA 649-677
Reactivity
All reactivities for Transferrin Receptor antibodies
Human
Host
All hosts for Transferrin Receptor antibodies
Mouse
Clonality
All clonalities for Transferrin Receptor antibodies
Monoclonal
Conjugate
All conjugates for Transferrin Receptor antibodies
This Transferrin Receptor antibody is un-conjugated
Application
All applications for Transferrin Receptor antibodies
Western Blotting (WB)
Purification
This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Immunogen
This TFRC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from human TFRC.
Clone
514CT23-4-1
Isotype
IgM
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Alternatives
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Application Details
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Application Notes
WB: 1:1000. WB: 1:100~250
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Target Details for Transferrin Receptor
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Target
Transferrin Receptor (TFRC)
(Transferrin Receptor (p90, CD71) (TFRC))
Alternative Name
TFRC (TFRC Products )
Synonyms
Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody
Background
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Molecular Weight
84871
NCBI Accession
NP_001121620 , NP_003225
UniProt
P02786
Pathways
Transition Metal Ion Homeostasis
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