ITPR1 antibody (pSer1756, pSer1764)
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- Target See all ITPR1 Antibodies
- ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
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Binding Specificity
- pSer1756, pSer1764
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ITPR1 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Phospho-IP3 Receptor (Ser1756) Antibody detects endogenous levels of IP3 Receptor only when phosphorylated at Ser1756.
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from RAT IP3 Receptor(P29994) around the phosphorylation site of Ser1756. This site is equivalent to Ser1764 in the human IP3 receptor sequence.
- Isotype
- IgG
- Top Product
- Discover our top product ITPR1 Primary Antibody
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- Application Notes
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
- Alternative Name
- ITPR1 (ITPR1 Products)
- Synonyms
- D6Pas2 antibody, ENSMUSG00000072853 antibody, Gm10429 antibody, IP3R1 antibody, InsP3R antibody, Ip3r antibody, Itpr-1 antibody, P400 antibody, Pcp-1 antibody, Pcp1 antibody, opt antibody, I145TR antibody, InsP3R1 antibody, INSP3R1 antibody, IP3R antibody, SCA15 antibody, SCA16 antibody, SCA29 antibody, inositol 1,4,5-trisphosphate receptor type 1 antibody, inositol 1,4,5-trisphosphate receptor 1 antibody, inositol 1,4,5-trisphosphate receptor, type 1 antibody, ITPR1 antibody, Itpr1 antibody
- Background
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Description: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Gene: ITPR1
- Molecular Weight
- 314kDa
- Gene ID
- 3708
- UniProt
- Q14643
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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