ZFP36L2 antibody (Internal Region)

Catalog No. ABIN6259621

Product Details anti-ZFP36L2 Antibody

Target: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFP36L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: TISD Antibody detects endogenous levels of total TISD.

Predicted Reactivity: Pig,Bovine,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TISD, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ZFP36L2

Target: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Alternative Name: ZFP36L2 (ZFP36L2 Products)

Synonyms: BRF2 antibody, ERF-2 antibody, ERF2 antibody, RNF162C antibody, TIS11D antibody, Brf2 antibody, Tis11d antibody, fi22c11 antibody, wu:fi22c11 antibody, zgc:76924 antibody, ZFP36L2 antibody, XC3H-3 antibody, XC3H-3b antibody, c3h-3 antibody, zfp36l2 antibody, brf2 antibody, erf-2 antibody, erf2 antibody, rnf162c antibody, tis11d antibody, cb198 antibody, cb480 antibody, fk89d11 antibody, id:ibd1247 antibody, sb:cb198 antibody, sb:cb480 antibody, wu:fb80h11 antibody, wu:fb92f07 antibody, wu:fk89d11 antibody, zfp36l1 antibody, zgc:153979 antibody, XC3H-2 antibody, berg36 antibody, brf1 antibody, c3h-2 antibody, cmg1 antibody, erf-1 antibody, erf1 antibody, rnf162b antibody, tis11b antibody, zfp36l1-a antibody, zfp36l1-b antibody, ZFP36 ring finger protein like 2 antibody, zinc finger protein 36, C3H type-like 2 antibody, ZFP36 ring finger protein-like 2 S homeolog antibody, ZFP36 ring finger protein-like 2 L homeolog antibody, ZFP36 ring finger protein-like 2 antibody, zinc finger protein 36, C3H type-like 1a antibody, ZFP36 ring finger protein-like 1 L homeolog antibody, ZFP36L2 antibody, Zfp36l2 antibody, zfp36l2 antibody, zfp36l2.S antibody, zfp36l2.L antibody, zfp36l1a antibody, zfp36l1.L antibody

Background:

Description: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Gene: ZFP36L2

Molecular Weight: 40 kDa

Gene ID: 678

UniProt: P47974

Pathways: Stem Cell Maintenance